Which side effect is commonly associated with beta-agonist bronchodilators such as albuterol?

Which side effect is commonly associated with beta-agonist bronchodilators such as albuterol?

• A. Tremor
• B. Nausea
• C. Hypokalemia
• D. Tachycardia

Answer: (D)

Beta-agonist bronchodilators primarily relax airway smooth muscle by activating beta-2 receptors, but some of the drug can enter the systemic circulation and stimulate heart receptors or increase sympathetic tone. This commonly manifests as an increased heart rate, i.e., tachycardia, which is the most frequently observed systemic side effect with inhaled agents like albuterol. Tremor can occur as well due to beta-2 effects on skeletal muscle, especially at higher doses, but tachycardia is more consistently reported. Mild hypokalemia can occur from potassium shifting into cells with beta-2 activation, but it’s less common and not as characteristic as tachycardia. Nausea is not a typical feature.

Beta-agonist bronchodilators primarily relax airway smooth muscle by activating beta-2 receptors, but some of the drug can enter the systemic circulation and stimulate heart receptors or increase sympathetic tone. This commonly manifests as an increased heart rate, i.e., tachycardia, which is the most frequently observed systemic side effect with inhaled agents like albuterol. Tremor can occur as well due to beta-2 effects on skeletal muscle, especially at higher doses, but tachycardia is more consistently reported. Mild hypokalemia can occur from potassium shifting into cells with beta-2 activation, but it’s less common and not as characteristic as tachycardia. Nausea is not a typical feature.